The 2-Process Model of Sleep
Learn how a homeostatic drive and the circadian clock control the timing of sleep
Entrainment Simulator
Explore basic concepts of circadian entrainment, phase response curves, and phase shifts with our Entrainment Simulator
Circadian Clock-Controlled Genes Part 1
An introductory tutorial video on the mechanisms of mammalian molecular circadian clock regulation, and how the clock regulates other genes.
Links Between Mood Disorders and Circadian Rhythms
Learn about the behavioral assays and gene manipulations used in rodent models to explore links between circadian rhythms and mood disorders
Photoperiodic Flowering Part 1
Discover how plants measure night- and day-length to determine when to flower
Photoperiodic Flowering Part 2
Part 2, the advanced mechanisms how plants measure night- and day-length to determine when to flower
Cellular Oscillators
Learn about "clocks in a dish," and how in vitro mammalian clocks can be used to study circadian rhythms
Fluence Response Curves and Action Spectra Series
Discover how action spectra are derived from fluence response curves
Phase Response Curves
Understand phase response curves, an important - but tricky! - circadian concept
Establishing the Genetic Basis of Circadian Rhythms: A Landmark Study
Learn about basic property of free-running periods of circadian oscillators
Effects of Sleep Deprivation on Attention and Mood
Learn about the effects of sleep deprivation on attention and mood.
The Suprachiasmatic Nucleus: Lesion & Transplant Experiments
Learn about landmark experiments that demonstrated the role of the suprachiasmatic nucleus (SCN) in circadian rhythms
Common Clock Mechanism Graphics Tool
Use our free editable powerpoint file of mammalian, fly, and plant molecular clock mechanisms in presentations and papers
Human Circadian Variation: Genetic Approaches
Learn how genetic manipulations in model organisms and in vitro establish circadian links to human variation in chronotype
Properties of Entrainable Oscillators
Learn the properties that define an entrainable biological circadian oscillator
Bioluminescent and Fluorescent Reporters in Circadian Rhythm Studies
Read about the biology, application, and experimental design of fluorescent reporters in circadian studies
Luciferase Reporters for Mammals in Circadian Research
Learn how luciferase reporters are used to study circadian rhythms in mammals
Cyanobacterial Circadian Oscillator
Discover how three proteins interact to make a circadian oscillator mechanism in the cyanobacterium Synechococcus elongatus