A major output of circadian systems is locomotor behavior. The following series explains how rodent wheel-running studies are performed and data are analyzed:

To conduct your own rodent wheel-running experiment, use our “Entrainment Simulator” to explore the effects of light exposure on circadian behavior.

Brain lesion and transplant studies were used with wheel-running to identify the region of the brain that regulates circadian rhythms in mammals, the suprachiasmatic nucleus.

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In addition to learning more about the suprachiasmatic nucleus and circadian rhythms, wheel running has been used to discover a light-independent circadian clock called the food-entrainable oscillator.